Thera-SAbDab

SIRUKUMAB

> Structural Summary

Therapeutic	Sirukumab
Target	IL6
Heavy Chain	EVQLVESGGGLVQPGGSLRLSCAASGFTFSPFAMSWVRQAPGKGLEWVAKISPGGSWTYYSDTVTGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLWGYYALDIWGQGTTVTVSS
Light Chain	EIVLTQSPATLSLSPGERATLSCSASISVSYMYWYQQKPGQAPRLLIYDMSNLASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCMQWSGYPYTFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

> SAbPred Links

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Preregistration (w)
Estimated Status (Feb '25)	Active
Recorded Developmental Technology
INN Year Proposed	2011
INN Year Recommended	2012
Companies Involved	Centocor Inc, GlaxoSmithKline, Janssen Biotech
Conditions Approved	na
Conditions Active	COVID-19
Conditions Discontinued	Rheumatoid arthritis, Atherosclerosis, Giant cell arteritis, Asthma, Lupus nephritis, Major depressive disorder
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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